HPA Axis Suppression: A Reversible Side Effect of Corticosteriod Usage

High-strength steroids used over large areas, or under occlusion, may be significantly absorbed into the body, causing hypothalamic-pituitary-adrenal axis suppression (HPA axis suppression).

Oregon State University:

Question: I am an eczema sufferer and have been suffering from moderate-severe eczema for the past 6 years. I notice some corticostereoid creams can say on the label that complications can arise from using it for a long period of time or on massive areas like I have been doing for the past years... one thing that it says can arise is "HPA axis suppresion" -- what does this mean and what are the symptoms? If I stop using the creams/ointments, will it go away? Thanks.

Answer: The HPA axis can be thought of as the body's "stress sytem". It controls the levels of cortisol (the "stress hormone") and other important stress-related hormones. The HPA axis can also be thought of as the body's energy regulator, because it is also responsible for controlling virtually all of the hormones, nervous system activity and energy expenditure in the human body, as well as modulating the immune system. When the HPA axis becomes suppressed, your body will not be able to properly regulate your stress and energy levels, which can manifest in fatigue, suppressed immune system, depression and anxiety. If you are experiencing such symptoms, you should see your health care provider for recommendations on the appropriate course of action.

FDA Experience: Topical Corticosteriods and HPA Access Suppression